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Abstract: Rabbits are popular pets and they are susceptible to injuries. Though various types of dressing materials have been available, the comparative analysis of the effectiveness of various dressing materials on external wound healing in rabbits is limited. So, the objective of this investigation is to assess the efficacy of Zinc oxide tape, Povidone Iodine, and Polyurethane film as wound dressing materials. Twenty rabbits were divided into four groups, each consisting of five rabbits: group A was the control group, group B was provided with zinc oxide tape, group C received 10% povidone iodine dressing, and polyurethane film was administered in group D. Each animal underwent three linear incisions, each 2 cm in length, in the flank area. The control group did not receive any dressing for external wound healing, whereas Groups B and D were administered zinc oxide tape and polyurethane film on day 0, and Group C got daily povidone iodine dressing. Morphological and histopathological changes of the wound sites were observed during the experiment. Full thickness skin tissue samples were obtained on days 3, 7, and 14 post-application of wound dressing materials. The wound length and width (1.28 ± 0.06 cm and 0.059 ± 0.0126 cm) were significantly decreased (ANOVA, p < 0.001, η² = 0.755 for length; η² = 0.737 for width) in 10% povidone iodine treated group compared to the zinc oxide tape group (1.46 ± 0.05 cm and 0.12 ± 0.06 cm), the polyurethane film (1.63 ± 0.03 cm and 0.193 ± 0.01 cm) and the control group (2.44 ± 0.05 cm and 0.251 ± 0.007 cm). The histological study revealed that 10% povidone iodine group exhibited the fastest reepithelialization, followed by zinc oxide tape, polyurethane f ilm and control group. The study demonstrated that regular dressing with 10% povidone iodine promoted enhanced wound healing compared to zinc oxide and polyurethane film, making it appropriate for wound dressings in rabbits.
Keywords: Zinc oxide tape, povidone iodine, polyurethane film, wound healing, antimicrobial agents
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